A list of global patches that affect gameplay mechanics:

Decheese:
 Disable Item Box
 Disable Screen Scroll
 
Dejank:
 Block Dejank for Thrown Items
 ON/OFF Double Hit Fix
 Wall Clips Disabled
 
Feature Changes:
 Bring Up Save Prompt by Pressing Select
 Cape Turnaround Patch (wherever indicated)
 Kevin's Retry
  Counter Break: Yes
  Lives: Infinite
  Midways: Save by pressing select on the overworld
  
Sprite Modifications:
 Placeable Disco Shell